A within-host mathematical model to assess the chicken immune response to influenza A (H9N2) virus vaccination and infection

Host Immune Response to Influenza A Virus Infection

Influenza A viruses (IAVs) are contagious pathogens responsible for severe respiratory infection in humans and animals worldwide. Upon detection of IAV infection, host immune system aims to defend against and clear the viral infection. Innate immune system is comprised of physical barriers (mucus and collectins), various phagocytic cells, group of cytokines, interferons (IFNs), and IFN-stimulat...

Chlamydia psittaci infection increases mortality of avian influenza virus H9N2 by suppressing host immune response

Avian influenza virus subtype H9N2 (H9N2) and Chlamydia psittaci (C. psittaci) are frequently isolated in chickens with respiratory disease. However, their roles in co-infection remain unclear. We tested the hypothesis that C. psittaci enhances H9N2 infection through suppression of host immunity. Thus, 10-day-old SPF chickens were inoculated intra-tracheally with a high or low virulence C. psit...

Histopathological Study of Intratracheally Inoculated A/Chicken/Iran/259/1998 (H9N2) Influenza Virus in Chicken

A Study on Histopathologic Changes in Chicken Following Intravenous Inoculation with Avian Influenza Virus A/Chicken/Iran/259/1998(H9N2)

necrotic response to low pathogenic h9n2 influenza virus in chicken hepatoma cells

conclusions taken together, these data reveal that cellular protease of chicken liver cells allows the replication of high yields of h9n2 virus in the absence of trypsin and also cell death in the infected cells is due to necrosis. results the degree of viability was significantly reduced in infected hepatoma cells. observations of caspase activation and cell dna laddering in infected cells wer...